A New Cytotoxic Chromen-C-Glucoside from the Leaves of Salvadora persica

The phytochemical investigation of the methanolic extract of the leaves of Salvadora persica afforded five known compounds identified as kampferol-3-O-β-glucopyranoside, Kaempferol-3,7di-O-β-glucopyranoside, quercetin-3',7-dimethylether, isobiflorin (5,7–dihydroxy-2methylchromone-8-C-β-glucopyranoside), biflorin (5,7–dihydroxy-2-methylchromone-6-C-βglucopyranoside), as well as a new cytotoxic chromen derivative; 5-hydroxy-7-methoxy-2methyl-4H-chromen-4-one-6-C-glucopyranoside. The structure characterization of the isolated compounds was based on MS and NMR spectral data. The cytotoxic activity of the new chromen glycoside was investigated against several cancer cell lines such as Hep-G2, MCF-7, MDA-MB231 and HT-29. The compound exhibited a cytotoxic activity against Hep-G2, whereas the activity was not significant against MCF-7, MDA-MB-231 and HT-29 cells.